Ketamine is a prescription-only medication with recognised medical uses, including anaesthesia and, in controlled clinical settings, treatment-resistant depression. It works by affecting glutamate activity in the brain, producing dissociative and analgesic effects. In the UK, ketamine is a controlled substance, and its use is strictly regulated and limited to licensed medical environments.

Outside approved medical supervision, ketamine carries significant risks, including cognitive impairment, dependency, bladder damage, and psychological effects. For safety and legal reasons, ketamine should only be accessed and administered by qualified healthcare professionals in accordance with UK law.